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Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold

Dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives were prepared by successive N3- and N1-alkylation of hydantoins, followed by regioselective thionation and subsequent cyclization under mild conditions. In a final alkylation step a further substituent may be introduced. The synthetic...

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Detalhes bibliográficos
Main Authors: Tzvetkov, Nikolay T, Euler, Harald, Müller, Christa E
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510990/
https://ncbi.nlm.nih.gov/pubmed/23209490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.8.181
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