Inhibition of PrP(Sc) formation in scrapie infected N2a cells by 5,7,8-trimethyl-3,4-dihydro-2H-1,4-benzoxazine derivatives

Prion diseases are fatal, neurodegenerative diseases characterized by the structural conversion of the normal, cellular prion protein, PrP(C) into an abnormally structured, aggregated and partially protease-resistant isoform, termed PrP(Sc). Although substantial research has been directed toward dev...

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Bibliografiske detaljer
Main Authors: Koukouli, Fani, Paspaltsis, Ioannis, Salta, Evgenia, Xanthopoulos, Konstantinos, Koini, Eftychia N., Calogeropoulou, Theodora, Sklaviadis, Theodoros
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510853/
https://ncbi.nlm.nih.gov/pubmed/22918434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.21913
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