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Inhibition of PrP(Sc) formation in scrapie infected N2a cells by 5,7,8-trimethyl-3,4-dihydro-2H-1,4-benzoxazine derivatives
Prion diseases are fatal, neurodegenerative diseases characterized by the structural conversion of the normal, cellular prion protein, PrP(C) into an abnormally structured, aggregated and partially protease-resistant isoform, termed PrP(Sc). Although substantial research has been directed toward dev...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510853/ https://ncbi.nlm.nih.gov/pubmed/22918434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.21913 |
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