A Bacterial Pathogen Co-opts Host Plasmin to Resist Killing by Cathelicidin Antimicrobial Peptides

The bacterial pathogen Group A Streptococcus (GAS) colonizes epithelial and mucosal surfaces and can cause a broad spectrum of human disease. Through the secreted plasminogen activator streptokinase (Ska), GAS activates human plasminogen into plasmin and binds it to the bacterial surface. The result...

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Bibliographische Detailangaben
Hauptverfasser: Hollands, Andrew, Gonzalez, David, Leire, Emma, Donald, Cortny, Gallo, Richard L., Sanderson-Smith, Martina, Dorrestein, Pieter C., Nizet, Victor
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510793/
https://ncbi.nlm.nih.gov/pubmed/23038245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404582
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