The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

The CCR4–NOT complex plays a crucial role in post-transcriptional mRNA regulation in eukaryotic cells. It catalyzes the removal of mRNA poly(A) tails, thereby repressing translation and committing mRNAs to decay. The conserved core of the complex consists of a catalytic module comprising two deadeny...

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Hlavní autoři: Petit, Alain-Pierre, Wohlbold, Lara, Bawankar, Praveen, Huntzinger, Eric, Schmidt, Steffen, Izaurralde, Elisa, Weichenrieder, Oliver
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510486/
https://ncbi.nlm.nih.gov/pubmed/22977175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks883
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