The Salmonella Kinase SteC Targets the MAP Kinase MEK to Regulate the Host Actin Cytoskeleton

After host cell entry, Salmonella replicate in membrane-bound compartments, which accumulate a dense meshwork of F-actin through the kinase activity of the Salmonella SPI-2 type III secretion effector SteC. We find that SteC promotes actin cytoskeleton reorganization by activating a signaling pathwa...

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Main Authors: Odendall, Charlotte, Rolhion, Nathalie, Förster, Andreas, Poh, John, Lamont, Douglas J., Liu, Mei, Freemont, Paul S., Catling, Andrew D., Holden, David W.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510437/
https://ncbi.nlm.nih.gov/pubmed/23159055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.09.011
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