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Influence of the Length of the Alanine Spacer on the Acidic–Basic Properties of the Ac–Lys–(Ala)(n)–Lys–NH(2) Peptides (n = 0, 1, 2, …, 5)

By using the potentiometric titration method, we have determined the pK (a) values of the two terminal lysine groups in six alanine-based peptides differing in the length of the alanine chain: Ac–Lys–Lys–NH(2) (KK), Ac–Lys–Ala–Lys–NH(2) (KAK), Ac–Lys–Ala–Ala–Lys–NH(2) (KAK2), Ac–Lys–Ala–Ala–Ala–Lys–...

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Detalhes bibliográficos
Main Authors: Makowska, Joanna, Liwo, Adam, Chmurzyński, Lech, Scheraga, Harold A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510421/
https://ncbi.nlm.nih.gov/pubmed/23204596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10953-012-9903-7
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