Dexamethasone Prodrug Treatment Prevents Nephritis in Lupus-prone (NZB×NZW)F1 Mice without Causing Systemic Side Effects

OBJECTIVE: To evaluate the potentially improved therapeutic efficacy and safety of nephrotropic macromolecular prodrugs of glucocorticoids (GC) in the treatment of lupus nephritis. METHODS: Monthly injection of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-based dexamethasone prodrug (P-Dex) an...

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Detalhes bibliográficos
Main Authors: Yuan, Fang, Nelson, Richard K., Tabor, Dana E., Zhang, Yijia, Akhter, Mohammed P., Gould, Karen A., Wang, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510353/
https://ncbi.nlm.nih.gov/pubmed/22886616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34667
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