Gastrin-Releasing Peptide Receptor Antagonism Induces Protection from Lethal Sepsis: Involvement of Toll-like Receptor 4 Signaling

In sepsis, toll-like receptor (TLR)-4 modulates the migration of neutrophils to infectious foci, favoring bacteremia and mortality. In experimental sepsis, organ dysfunction and cytokines released by activated macrophages can be reduced by gastrin-releasing peptide (GRP) receptor (GRPR) antagonist R...

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Autori principali: Petronilho, Fabricia, Vuolo, Francieli, Galant, Letícia Selinger, Constantino, Larissa, Tomasi, Cristiane Damiani, Giombelli, Vinicius Renne, de Souza, Cláudio Teodoro, da Silva, Sabrina, Barbeiro, Denise Frediani, Soriano, Francisco Garcia, Streck, Emílio Luiz, Ritter, Cristiane, Zanotto-Filho, Alfeu, Pasquali, Matheus Augusto, Gelain, Daniel Pens, Rybarczyk-Filho, José Luiz, Moreira, José Cláudio Fonseca, Block, Norman L, Roesler, Rafael, Schwartsmann, Gilberto, Schally, Andrew V, Dal-Pizzol, Felipe
Natura: Artigo
Lingua:Inglês
Pubblicazione: ScholarOne 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510294/
https://ncbi.nlm.nih.gov/pubmed/22735756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2012.00083
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