Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica

BACKGROUND AND METHODS: The aim of this study was to develop an immediate-release pellet formulation with improved drug dissolution and adsorption. Carbamazepine, a poorly water-soluble drug, was adsorbed into mesoporous silica (SBA-15-CBZ) via a wetness impregnation method and then processed by ext...

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Главные авторы: Wang, Zhouhua, Chen, Bao, Quan, Guilan, Li, Feng, Wu, Qiaoli, Dian, Linghui, Dong, Yixuan, Li, Ge, Wu, Chuanbin
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2012
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509994/
https://ncbi.nlm.nih.gov/pubmed/23209366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S37650
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