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Crystallization and preliminary X-ray analysis of the open form of human ecto-5′-nucleotidase (CD73)

Eukaryotic ecto-5′-nucleotidase (e5NT) catalyses the hydrolysis of extracellular AMP to adenosine and plays a pivotal role in switching on adenosine signalling via the P1 receptors of the purinergic signalling pathway. With such an important regulatory role, e5NT has become an appealing new drug tar...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Knapp, Karen Maree, Zebisch, Matthias, Sträter, Norbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509985/
https://ncbi.nlm.nih.gov/pubmed/23192044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112045447
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