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Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up

A library of approximately 40 N(1)-acylated (aza)indole alkanoic esters and acids was prepared employing a microwave-assisted approach. The optimized synthetic route allows for parallel synthesis, variation of the indole substitution pattern and high overall yield. Additionally, the procedure has be...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liedtke, Andy J., Kim, Kwangho, Stec, Donald F., Sulikowski, Gary A., Marnett, Lawrence J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509943/
https://ncbi.nlm.nih.gov/pubmed/23204595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2012.08.044
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