Abruption-Induced Preterm Delivery Is Associated with Thrombin-Mediated Functional Progesterone Withdrawal in Decidual Cells

Plasma progesterone levels remain elevated throughout human pregnancy, suggesting that reduced reproductive-tract progesterone receptor (PR) initiates labor. Placental abruption and excess thrombin generation elicit preterm delivery (PTD). PR, glucocorticoid receptor (GR), and total and p-ERK1/2 in...

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Detalhes bibliográficos
Main Authors: Lockwood, Charles J., Kayisli, Umit A., Stocco, Carlos, Murk, William, Vatandaslar, Emre, Buchwalder, Lynn F., Schatz, Frederick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509762/
https://ncbi.nlm.nih.gov/pubmed/23058370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.08.036
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