IFN-γ Receptor Deficient Donor T cells Mediate Protection from Graft-versus-Host Disease and Preserve Graft-versus-Tumor Responses After Allogeneic Bone Marrow Transplantation

Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT). It has been previously reported that lung GVHD severity directly correlates with the expansion of donor Th17 cells in the absence of IFN-γ. However, the consequence of Th17-associated lung GVHD...

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Detalhes bibliográficos
Main Authors: Sun, Kai, Hsiao, Hui-Hua, Li, Minghui, Ames, Erik, Bouchlaka, Myriam, Welniak, Lisbeth A., Hagino, Takeshi, Jagdeo, Jared, Pai, Chien-Chun, Chen, Mingyi, Blazar, Bruce R., Abedi, Mehrdad, Murphy, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509544/
https://ncbi.nlm.nih.gov/pubmed/22778394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102853
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