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Leucettamols, Bifunctionalized Marine Sphingoids, Act as Modulators of TRPA1 and TRPM8 Channels

Leucettamols, bifunctionalized sphingoid-like compounds obtained from a marine sponge Leucetta sp., act as non-electrophilic activators of the TRPA1 channel and potent inhibitors of the icilin-mediated activation of the TRPM8 channel, while they are inactive on CB(1), CB(2) and TRPV1 receptors. Leuc...

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Detalhes bibliográficos
Main Authors: Chianese, Giuseppina, Fattorusso, Ernesto, Putra, Masteria Yunovilsa, Calcinai, Barbara, Bavestrello, Giorgio, Moriello, Aniello Schiano, Petrocellis, Luciano De, Marzo, Vincenzo Di, Taglialatela-Scafati, Orazio
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509527/
https://ncbi.nlm.nih.gov/pubmed/23203269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md10112435
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