mTrop1/Epcam Knockout Mice Develop Congenital Tufting Enteropathy through Dysregulation of Intestinal E-cadherin/β-catenin

Congenital tufting enteropathy (CTE) is a life-threatening hereditary disease that is characterized by enteric mucosa tufting degeneration and early onset, severe diarrhea. Loss-of-function mutations of the human EPCAM gene (TROP1, TACSTD1) have been indicated as the cause of CTE. However, loss of m...

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Detalhes bibliográficos
Main Authors: Guerra, Emanuela, Lattanzio, Rossano, La Sorda, Rossana, Dini, Francesca, Tiboni, Gian Mario, Piantelli, Mauro, Alberti, Saverio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509129/
https://ncbi.nlm.nih.gov/pubmed/23209569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049302
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