Ebola Virus Genome Plasticity as a Marker of Its Passaging History: A Comparison of In Vitro Passaging to Non-Human Primate Infection

To identify polymorphic sites that could be used as biomarkers of Ebola virus passage history, we repeatedly amplified Ebola virus (Kikwit variant) in vitro and in vivo and performed deep sequencing analysis of the complete genomes of the viral subpopulations. We then determined the sites undergoing...

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Auteurs principaux: Kugelman, Jeffrey R., Lee, Michael S., Rossi, Cynthia A., McCarthy, Sarah E., Radoshitzky, Sheli R., Dye, John M., Hensley, Lisa E., Honko, Anna, Kuhn, Jens H., Jahrling, Peter B., Warren, Travis K., Whitehouse, Chris A., Bavari, Sina, Palacios, Gustavo
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509072/
https://ncbi.nlm.nih.gov/pubmed/23209706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050316
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