SIB-DOTA: A trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies

A major drawback of internalizing monoclonal antibodies (mAbs) radioiodinated with direct electrophilic approaches is that tumor retention of radioactivity is compromised by the rapid washout of iodo-tyrosine, the primary labeled catabolite for mAbs labeled via this strategy. In our continuing effor...

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Main Authors: Vaidyanathan, G., White, B. J., Affleck, D.J., Zhao, X.G., Welsh, P.C., McDougald, D., Choi, J., Zalutsky, M. R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508367/
https://ncbi.nlm.nih.gov/pubmed/23159039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.10.025
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