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Crystal Structure of the Hexachlorocyclohexane Dehydrochlorinase (LinA-Type2): Mutational Analysis, Thermostability and Enantioselectivity

Hexachlorocyclohexane dehydrochlorinase (LinA) mediates dehydrochlorination of γ-HCH to 1, 3, 4, 6-tetrachloro-1,4-cyclohexadiene that constitutes first step of the aerobic degradation pathway. We report the 3.5 Å crystal structure of a thermostable LinA-type2 protein, obtained from a soil metagenom...

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Autors principals: Macwan, Ankit S., Kukshal, Vandna, Srivastava, Nidhi, Javed, Saleem, Kumar, Ashwani, Ramachandran, Ravishankar
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507683/
https://ncbi.nlm.nih.gov/pubmed/23209726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050373
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