The Crystal Structure of the Intact E. coli RelBE Toxin-Antitoxin Complex Provides the Structural Basis for Conditional Cooperativity

The bacterial relBE locus encodes a toxin-antitoxin complex in which the toxin, RelE, is capable of cleaving mRNA in the ribosomal A site cotranslationally. The antitoxin, RelB, both binds and inhibits RelE, and regulates transcription through operator binding and conditional cooperativity controlle...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bøggild, Andreas, Sofos, Nicholas, Andersen, Kasper R., Feddersen, Ane, Easter, Ashley D., Passmore, Lori A., Brodersen, Ditlev E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2012
Schlagworte:
Short Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507626/
https://ncbi.nlm.nih.gov/pubmed/22981948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.017
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