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Metformin and the Risk of Cancer: Time-related biases in observational studies

OBJECTIVE: Time-related biases in observational studies of drug effects have been described extensively in different therapeutic areas but less so in diabetes. Immortal time bias, time-window bias, and time-lag bias all tend to greatly exaggerate the benefits observed with a drug. RESEARCH DESIGN AN...

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Bibliographic Details
Main Authors: Suissa, Samy, Azoulay, Laurent
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507580/
https://ncbi.nlm.nih.gov/pubmed/23173135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc12-0788
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