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Oligonucleotide Delivery by Nucleofection Does Not Rescue the Reduced Proliferation Phenotype of Gene-Edited Cells

Gene editing using single-stranded oligonucleotides (ODNs) can be used to reverse or create a single base mutation in mammalian cells. This approach could be used to treat genetic diseases caused, at least in part, by a nucleotide substitution. The technique could also be used as a tool to establish...

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Autori principali: Livingston, Paula, Strouse, Bryan, Perry, Haley, Borjigin, Mandula, Bialk, Pawel, Kmiec, Eric B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507522/
https://ncbi.nlm.nih.gov/pubmed/23072627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2012.0374
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