Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGFβ Suppression

ETS transcription factors ETV2, FLI1 and ERG1 specify pluripotent stem cells into endothelial cells (ECs). However, these ECs are unstable and drift towards non-vascular cell fates. We show that human mid-gestation c-Kit(−) lineage-committed amniotic cells (ACs) can be readily reprogrammed into indu...

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Detalhes bibliográficos
Main Authors: Ginsberg, Michael, James, Daylon, Ding, Bi-Sen, Nolan, Daniel, Geng, Fuqiang, Butler, Jason M, Schachterle, William, Pulijaal, Venkat R, Mathew, Susan, Chasen, Stephen T, Xiang, Jenny, Rosenwaks, Zev, Shido, Koji, Elemento, Olivier, Rabbany, Sina Y, Rafii, Shahin
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507451/
https://ncbi.nlm.nih.gov/pubmed/23084400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.032
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