Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency

ISG15 is an interferon (IFN)-α/β-inducible, ubiquitin-like intracellular protein. Its conjugation to various proteins (ISGylation) contributes to antiviral immunity in mice. We describe human patients with inherited ISG15 deficiency and mycobacterial, but not viral diseases. The lack of intracellula...

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Detalhes bibliográficos
Main Authors: Bogunovic, Dusan, Byun, Minji, Durfee, Larissa A., Abhyankar, Avinash, Sanal, Ozden, Mansouri, Davood, Salem, Sandra, Radovanovic, Irena, Grant, Audrey V., Adimi, Parisa, Mansouri, Nahal, Okada, Satoshi, Bryant, Vanessa L., Kong, Xiao-Fei, Kreins, Alexandra, Velez, Marcela Moncada, Boisson, Bertrand, Khalilzadeh, Soheila, Ozcelik, Ugur, Darazam, Ilad Alavi, Schoggins, John W., Rice, Charles M., Al-Muhsen, Saleh, Behr, Marcel, Vogt, Guillaume, Puel, Anne, Bustamante, Jacinta, Gros, Philippe, Huibregtse, Jon M., Abel, Laurent, Boisson-Dupuis, Stéphanie, Casanova, Jean-Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507439/
https://ncbi.nlm.nih.gov/pubmed/22859821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1224026
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