Activation of Innate Immunity is Required for Efficient Nuclear Reprogramming

Retroviral overexpression of reprogramming factors (Oct4, Sox2, Klf4, c-Myc) generates induced pluripotent stem cells (iPSCs). However, the integration of foreign DNA could induce genomic dysregulation. Cell-permeant proteins (CPPs) could overcome this limitation. To date this approach has proved ex...

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Autori principali: Lee, Jieun, Sayed, Nazish, Hunter, Arwen, Au, Kin Fai, Wong, Wing H., Mocarski, Edward S., Pera, Renee Reijo, Yakubov, Eduard, Cooke, John P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506423/
https://ncbi.nlm.nih.gov/pubmed/23101625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.09.034
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