Positive Allosteric Modulation of mGluR5 Accelerates Extinction Learning but Not Relearning Following Methamphetamine Self-Administration

Recent studies have implicated glutamate neurotransmission as an important substrate for the extinction of conditioned behaviors, including responding for drug reinforcement. Positive allosteric modulation of the type-5 metabotropic glutamate receptor (mGluR5) in particular has emerged as a treatmen...

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Bibliographic Details
Main Authors: Kufahl, Peter R., Hood, Lauren E., Nemirovsky, Natali E., Barabas, Piroska, Halstengard, Casey, Villa, Angel, Moore, Elisabeth, Watterson, Lucas R., Olive, M. Foster
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2012
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506114/
https://ncbi.nlm.nih.gov/pubmed/23189054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00194
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