Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease

BACKGROUND AND PURPOSE: MELAS (mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes) is a mitochondrial disease most usually caused by point mutations in tRNA genes encoded by mitochondrial DNA (mtDNA). Approximately 80% of cases of MELAS syndrome are associated with a m.3243A &...

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Detalhes bibliográficos
Main Authors: Garrido-Maraver, Juan, Cordero, Mario D, Moñino, Irene Domínguez, Pereira-Arenas, Sheila, Lechuga-Vieco, Ana V, Cotán, David, De la Mata, Mario, Oropesa-Ávila, Manuel, De Miguel, Manuel, Bautista Lorite, Juan, Rivas Infante, Eloy, Álvarez-Dolado, Manuel, Navas, Plácido, Jackson, Sandra, Francisci, Silvia, Sánchez-Alcázar, José A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504996/
https://ncbi.nlm.nih.gov/pubmed/22747838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02086.x
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