Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity

Unlike other serine proteases that are zymogens, the single-chain form of tissue plasminogen activator (sc-tPA) exhibits an intrinsic activity similar to that of its cleaved two-chain form (tc-tPA), especially in the presence of fibrin. In the central nervous system tPA controls brain functions and...

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Bibliografiske detaljer
Main Authors: Parcq, J, Bertrand, T, Montagne, A, Baron, A F, Macrez, R, Billard, J M, Briens, A, Hommet, Y, Wu, J, Yepes, M, Lijnen, H R, Dutar, P, Anglés-Cano, E, Vivien, D
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504712/
https://ncbi.nlm.nih.gov/pubmed/22743997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.86
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