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Isolation and characterization of a Pseudomonas aeruginosa mutant producing a nontoxic, immunologically crossreactive toxin A protein.

Nitrosoguanidine mutagenesis of Pseudomonas aeruginosa strain PAO-1 yielded a mutant strain, PAO-PR1, which produced a protein that was immunologically indistinguishable from native toxin A and was nontoxic for cultured Chinese hamster ovary cells. In contrast to native toxin, the cell-associated an...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cryz, S J, Friedman, R L, Iglewski, B H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350469/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6261247/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.12.7199
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