Deoxycorticosterone biosynthesis in human kidney: potential for formation of a potent mineralocorticosteroid in its site of action.

The extra-adrenal formation of deoxycorticosterone (DOC) from plasma progesterone has been demonstrated in humans. In those studies it was shown that in some persons the volume of plasma cleared of progesterone by DOC formation was great, namely, 75 liter/24 hr. Because steroid 231-hydroxylase activ...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Winkel, C A, Simpson, E R, Milewich, L, MacDonald, P C
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1980
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350442/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6971442/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.12.7069
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