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Differential Trafficking of TLR1 I602S Underlies Host Protection Against Pathogenic Mycobacteria
We have recently identified I602S as a frequent single nucleotide polymorphism of human TLR1 which greatly inhibits cell surface trafficking, confers hyporesponsiveness to TLR1 agonists, and protects against the mycobacterial diseases leprosy and tuberculosis. Since mycobacteria are known to manipul...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504178/ https://ncbi.nlm.nih.gov/pubmed/23105135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201545 |
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