Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target

Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of kidney cancer. Here, we integrated an unbiased genome-wide RNA interference screen for ccRCC survival regulators with an analysis of recurrently overexpressed genes in ccRCC to identify new therapeutic targets in this...

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Detalles Bibliográficos
Autores principales: Gerlinger, Marco, Santos, Claudio R, Spencer-Dene, Bradley, Martinez, Pierre, Endesfelder, David, Burrell, Rebecca A, Vetter, Marcus, Jiang, Ming, Saunders, Rebecca E, Kelly, Gavin, Dykema, Karl, Rioux-Leclercq, Nathalie, Stamp, Gordon, Patard, Jean Jacques, Larkin, James, Howell, Michael, Swanton, Charles
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Ltd. 2012
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Original Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504091/
https://ncbi.nlm.nih.gov/pubmed/22362593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4006
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