Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations.

The morphologic transformation induced in Syrian hamster embryo cells by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) (0.25 microgram/ml of medium) is inhibited by posttreatment with antipain (6-600 microgram/ml), a protease inhibitor, but is unaffected by pretreatment. DNA replication relative to un...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	DiPaolo, J A, Amsbaugh, S C, Popescu, N C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1980
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350344/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6935676/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.11.6649
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