KU-32, a Novel Drug for Diabetic Neuropathy, Is Safe for Human Islets and Improves In Vitro Insulin Secretion and Viability

KU-32 is a novel, novobiocin-based Hsp90 inhibitor that protects against neuronal glucotoxicity and reverses multiple clinical indices of diabetic peripheral neuropathy in a rodent model. However, any drug with potential for treating diabetic complications must also have no adverse effects on the fu...

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Detalhes bibliográficos
Main Authors: Farmer, Kevin, Williams, S. Janette, Novikova, Lesya, Ramachandran, Karthik, Rawal, Sonia, Blagg, Brian S. J., Dobrowsky, Rick, Stehno-Bittel, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503326/
https://ncbi.nlm.nih.gov/pubmed/23197975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/671673
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