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Microfluidics separation reveals the stem-cell–like deformability of tumor-initiating cells

Here we report a microfluidics method to enrich physically deformable cells by mechanical manipulation through artificial microbarriers. Driven by hydrodynamic forces, flexible cells or cells with high metastatic propensity change shape to pass through the microbarriers and exit the separation devic...

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Détails bibliographiques
Auteurs principaux: Zhang, Weijia, Kai, Kazuharu, Choi, Dong Soon, Iwamoto, Takayuki, Nguyen, Yen H., Wong, Helen, Landis, Melissa D., Ueno, Naoto T., Chang, Jenny, Qin, Lidong
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503214/
https://ncbi.nlm.nih.gov/pubmed/23112172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209893109
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