Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

Autophagy is a cell biological pathway affecting immune responses. In vitro, autophagy acts as a cell-autonomous defense against Mycobacterium tuberculosis, but its role in vivo is unknown. Here we show that autophagy plays a dual role against tuberculosis: antibacterial and anti-inflammatory. M. tu...

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Detalhes bibliográficos
Main Authors: Castillo, Eliseo F., Dekonenko, Alexander, Arko-Mensah, John, Mandell, Michael A., Dupont, Nicolas, Jiang, Shanya, Delgado-Vargas, Monica, Timmins, Graham S., Bhattacharya, Dhruva, Yang, Hongliang, Hutt, Julie, Lyons, C. Rick, Dobos, Karen M., Deretic, Vojo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503152/
https://ncbi.nlm.nih.gov/pubmed/23093667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210500109
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