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ATP depletion as a consequence of adenosine deaminase inhibition in man.

Hereditary deficiency of the enzyme adenosie deaminase (adenosine aminohydrolase, EC 3.5.4.4) results in an immunodeficiency syndrome characterized by a marked reduction in circulating lymphocytes. We have administered 2'-deoxycoformycin, a potent inhibitor of adenosine deaminase, to a patient with...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Siaw, M F, Mitchell, B S, Koller, C A, Coleman, M S, Hutton, J J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350233/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6969403/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.10.6157
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