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Trimethyl lock: A trigger for molecular release in chemistry, biology, and pharmacology

The trimethyl lock is an o-hydroxydihydrocinnamic acid derivative in which unfavorable steric interactions between three pendant methyl groups encourage lactonization to form a hydrocoumarin. This reaction is extremely rapid, even when the electrophile is an amide and the leaving group is an amino g...

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Bibliografiske detaljer
Main Authors: Levine, Michael N., Raines, Ronald T.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501758/
https://ncbi.nlm.nih.gov/pubmed/23181187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2SC20536J
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