Genetic Variation of SCNN1A Influences Lung Diffusing Capacity in Cystic Fibrosis

INTRODUCTION: Epithelial Na(+) Channels (ENaC) play a crucial role in ion and fluid regulation in the lung. In cystic fibrosis (CF) Na(+) hyperabsorption results from ENaC over activity, leading to airway dehydration. Previous work has demonstrated functional genetic variation of SCNN1A (the gene en...

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Huvudupphovsmän: Baker, Sarah E., Wong, Eric C., Wheatley, Courtney M., Foxx-Lupo, William T., Martinez, Marina G., Morgan, Mary A., Sprissler, Ryan, Morgan, Wayne J., Snyder, Eric M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501594/
https://ncbi.nlm.nih.gov/pubmed/22776878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1249/MSS.0b013e318266ebc3
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