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Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes

Rett Syndrome (RTT) is a severe neurological disorder in young females, and is caused by mutations in the X-linked MECP2 gene. MECP2/Mecp2 gene encodes for two protein isoforms; MeCP2E1 and MeCP2E2 that are identical except for the N-terminus region of the protein. In brain, MECP2E1 transcripts are...

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Bibliografske podrobnosti
Main Authors: Zachariah, Robby M., Olson, Carl O., Ezeonwuka, Chinelo, Rastegar, Mojgan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501454/
https://ncbi.nlm.nih.gov/pubmed/23185431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049763
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