Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13

BACKGROUND: Interleukin-25 (IL-25) is a potent activator of type-2 immune responses. Mucosal inflammation in ulcerative colitis is driven by type-2 cytokines. We have previously shown that a neutralizing anti-IL-25 antibody abrogated airways hyperreactivity in an experimental model of lung allergy....

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Autori principali: Camelo, Ana, Barlow, Jillian L., Drynan, Lesley F., Neill, Daniel R., Ballantyne, Sarah J., Wong, See Heng, Pannell, Richard, Gao, Wei, Wrigley, Keely, Sprenkle, Justin, McKenzie, Andrew N. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Japan 2012
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Original Article—Alimentary Tract
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501170/
https://ncbi.nlm.nih.gov/pubmed/22539101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-012-0591-2
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