Non-proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation

[Image: see text] Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain the thioether structures lanthionine and methyllanthionine and exert potent antimicrobial activity against Gram-positive bacteria. At present, detailed modes-of-action a...

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Autors principals: Knerr, Patrick J., Oman, Trent J., Garcia De Gonzalo, Chantal V., Lupoli, Tania J., Walker, Suzanne, van der Donk, Wilfred A.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501146/
https://ncbi.nlm.nih.gov/pubmed/22920239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300372b
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