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A Limited 4 Å Radial Displacement of the S4-S5 Linker Is Sufficient for Internal Gate Closing in Kv Channels

Voltage-gated ion channels are responsible for the generation of action potentials in our nervous system. Conformational rearrangements in their voltage sensor domains in response to changes of the membrane potential control pore opening and thus ion conduction. Crystal structures of the open channe...

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Bibliografiska uppgifter
Huvudupphovsmän: Faure, Élise, Starek, Greg, McGuire, Hugo, Bernèche, Simon, Blunck, Rikard
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501078/
https://ncbi.nlm.nih.gov/pubmed/23019337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415497
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