Targeting the Unique Methylation Pattern of Androgen Receptor (AR) Promoter in Prostate Stem/Progenitor Cells with 5-Aza-2′-deoxycytidine (5-AZA) Leads to Suppressed Prostate Tumorigenesis

Androgen receptor (AR) expression surveys found that normal prostate/prostate cancer (PCa) stem/progenitor cells, but not embryonic or mesenchymal stem cells, expressed little AR with high methylation in the AR promoter. Mechanism dissection revealed that the differential methylation pattern in the...

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Hlavní autoři: Tian, Jing, Lee, Soo Ok, Liang, Liang, Luo, Jie, Huang, Chiung-Kuei, Li, Lei, Niu, Yuanjie, Chang, Chawnshang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501037/
https://ncbi.nlm.nih.gov/pubmed/23012352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.395574
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