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Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

N6-Cyclohexyl[3H]adenosine ([3H]CHA) and 1,3-diethyl-8-[3H]phenylxanthine ([3H]DPX) to bind to adenosine receptors in brain membranes. The agonist [3H]CHA has high affinity in both bovine and guinea pig brain (Kd, 0.7 nM and 6 nM, respectively). [3H]CHA binding kinetics are slow (dissociation t1/2;6...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Bruns, R F, Daly, J W, Snyder, S H
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1980
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350099/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6254090/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.9.5547
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