Trk Activation of the ERK1/2 Kinase Pathway Stimulates Intermediate Chain Phosphorylation and Recruits Cytoplasmic Dynein to Signaling Endosomes for Retrograde Axonal Transport

The retrograde transport of Trk-containing endosomes from the axon to the cell body by cytoplasmic dynein is necessary for axonal and neuronal survival. We investigated the recruitment of dynein to signaling endosomes in rat embryonic neurons and PC12 cells. We identified a novel phosphoserine on th...

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Main Authors: Mitchell, David J., Blasier, Kiev R., Jeffery, Erin D., Ross, Mitchell W., Pullikuth, Ashok K., Suo, Dong, Park, Juyeon, Smiley, W. Russell, Lo, Kevin W.-H., Shabanowitz, Jeffrey, Deppmann, Christopher D., Trinidad, Jonathan C., Hunt, Donald F., Catling, Andrew D., Pfister, K. Kevin
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2012
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500848/
https://ncbi.nlm.nih.gov/pubmed/23115187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5599-11.2012
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