Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion

Dynamic actin cytoskeletal reorganization is integral to cell motility. Profilins are well-characterized regulators of actin polymerization; however, functional differences among co-expressed profilin isoforms are not well defined. Here, we demonstrate that profilin-1 and profilin-2 differentially r...

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Bibliographic Details
Main Authors: Mouneimne, Ghassan, Hansen, Scott D., Selfors, Laura M., Petrak, Lara, Hickey, Michele M., Gallegos, Lisa L., Simpson, Kaylene J., Lim, James, Gertler, Frank B., Hartwig, John H., Mullins, R. Dyche, Brugge, Joan S.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500527/
https://ncbi.nlm.nih.gov/pubmed/23153535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.09.027
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