Identification of FoxM1/Bub1b signaling pathway as a required component for growth and survival of rhabdomyosarcoma

We identified Bub1b as an essential element for the growth and survival of rhabdomyosarcoma (RMS) cells using a bar-coded, tetracycline-inducible shRNA library screen. Knockdown of Bub1b resulted in suppression of tumor growth in vivo, including the regression of established tumors. The mechanism by...

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Hauptverfasser: Wan, Xiaolin, Choh, Yeung, Kim, Su Young, Dolan, Joseph G., Ngo, Vu N., Burkett, Sandra, Khan, Javed, Staudt, Louis M., Helman, Lee J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500453/
https://ncbi.nlm.nih.gov/pubmed/23002205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1991
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