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De novo Engineering of a Human Cystathionine-γ-Lyase for Systemic l-Methionine Depletion Cancer Therapy
It has been known for nearly a half century that human tumors, including those derived from the nervous system such as glioblastomas, medulloblastoma, and neuroblastomas are much more sensitive than normal tissues to l-Met starvation. More recently, systemic l-Met depletion by administration of Pseu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500410/ https://ncbi.nlm.nih.gov/pubmed/22963240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300335j |
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