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Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family
Resistance to platinum-based therapies arises by multiple mechanisms, including by alterations to cell-cycle kinases that mediate G2/M phase arrest. In this study, we conducted parallel high-throughput screens for microRNAs (miRNAs) that could restore sensitivity to cisplatin-resistant cells, and we...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500396/ https://ncbi.nlm.nih.gov/pubmed/22942255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1400 |
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