Candesartan, an Angiotensin II AT(1)-Receptor Blocker and PPAR-γ Agonist, Reduces Lesion Volume and Improves Motor and Memory Function After Traumatic Brain Injury in Mice

Traumatic brain injury (TBI) results in complex pathological reactions, the initial lesion worsened by secondary inflammation and edema. Angiotensin II (Ang II) is produced in the brain and Ang II receptor type 1 (AT(1)R) overstimulation produces vasoconstriction and inflammation. Ang II receptor bl...

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Bibliografiske detaljer
Main Authors: Villapol, Sonia, Yaszemski, Alexandra K, Logan, Trevor T, Sánchez-Lemus, Enrique, Saavedra, Juan M, Symes, Aviva J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499714/
https://ncbi.nlm.nih.gov/pubmed/22892395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.152
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